Dye diffusion from microcapsules with different shell thickness into mammalian skin

Yow, Huai Nyin and Wu, Xiao and Routh, Alexander F. and Guy, Richard H. (2009) Dye diffusion from microcapsules with different shell thickness into mammalian skin. European Journal of Pharmaceutics and Biopharmaceutics, 72 (1). pp. 62-68. ISSN 0939-6411 DOI 10.1016/j.ejpb.2008.11.004

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Abstract

Oil-in-water microcapsules with varying shell thicknesses were fabricated via a coacervation technique, whereby evaporation of volatile solvents induced the shell-forming polymer to precipitate, phase separate and migrate to the oil/water interface to form microcapsules. These microcapsules encapsulated a lipophilic dye within their cores and were applied topically onto porcine skin for 6 h. Results indicated that the dye preferentially accumulated within the skin furrows and hair follicles, though the dye did not penetrate beyond the stratum corneum. A model estimates the diffusion coefficients of dye through the microcapsule shell and within the skin to be approximately 10-18 and 10-16 m2 s-1, respectively.

Item Type:	Article
Uncontrolled Keywords:	BPI; 09AREP
Subjects:	99 - Other
Divisions:	99 - Other
Journal or Publication Title:	European Journal of Pharmaceutics and Biopharmaceutics
Volume:	72
Page Range:	pp. 62-68
Identification Number:	10.1016/j.ejpb.2008.11.004
Depositing User:	Sarah Humbert
Date Deposited:	22 Jul 2010 11:42
Last Modified:	23 Jul 2013 09:57
URI:	http://eprints.esc.cam.ac.uk/id/eprint/1500

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