Histamine releases PGI2 from human pulmonary artery

Schellenberg, R.Robert and Duff, Marilyn J. and Foster, Aidan and Paddon, Harry B. (1986) Histamine releases PGI2 from human pulmonary artery. Prostaglandins, 32 (2). pp. 201-209. DOI 10.1016/0090-6980(86)90125-5

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Abstract

<p><br/>Histamine caused a triphasic response of human pulmonary artery strips in vitro, consisting of a small initial contraction followed by pronounced relaxation preceding a second contractile response. These characteristics were not seen with other contractile stimuli including 5-hdyroxytryptamine, leukotriene D4, and KC1. The relaxant component of this response was ablated by removal of endothelium from the vascular strips or by pretreatment of the tissues with 1[mu]M indomethacin. Measurement of the PGI2 degradation product 6-keto-PGF1[alpha] in supernatants from histamine-challenged tissues confirmed the synthesis of PGI2. Supernatants from unstimulated or leukotriene-challenged tissues contained no detectable amounts of 6-keto-PGF1[alpha]. The histamine H1 antagonist diphenhydramine inhibited both the contractile and relaxant responses to histamine whereas the H2 antagonist cimetidine affected neither component. The released PGI2 significantly altered the dose-respons curve to histamine without inhibiting the maximal contractile responses. We conclude that histamine induces PGI2 formation from pulmonary arterial endothelium via an H1 receptor.</p>

Item Type: Article
Subjects: 02 - Geodynamics, Geophysics and Tectonics
Divisions: 99 - Other
Journal or Publication Title: Prostaglandins
Volume: 32
Page Range: pp. 201-209
Identification Number: 10.1016/0090-6980(86)90125-5
Depositing User: Sarah Humbert
Date Deposited: 11 Aug 2011 13:32
Last Modified: 23 Jul 2013 10:02
URI: http://eprints.esc.cam.ac.uk/id/eprint/2154

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