Anderson, Hugh J and Loader, Charles E and Foster, Aidan (1980) Pyrrole chemistry. XXII. A "one-pot" synthesis of some 4-acylpyrrole-2-carboxaldehydesfrom pyrrole. Canadian Journal of Chemistry, 58 (23). pp. 2527-2530. DOI 10.1139/v80-404Full text not available from this repository.
The Vilsmeier-Haack intermediates formed from pyrroleand from 1-methylpyrrole may be acylated under normal Friedel-Crafts conditions. Hydrolytic work-up then gives 4-acylpyrrole-2-carboxaldehydes in good yield. The methoxidelmethanol treatment of the 4-trichloroacetylated intermediate leads to methyl 2-formylpyrrole-4-carboxylate. These are all "one-pot" syntheses from pyrrole. The formyl group has been removed from several of the products thus affording some 3-acylpyrroles in two operations.
|Subjects:||99 - Other|
|Divisions:||99 - Other|
|Journal or Publication Title:||Canadian Journal of Chemistry|
|Page Range:||pp. 2527-2530|
|Depositing User:||Sarah Humbert|
|Date Deposited:||26 Oct 2011 09:26|
|Last Modified:||23 Jul 2013 10:02|
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