Anderson, Hugh J and Loader, Charles E and Foster, Aidan (1980) Pyrrole chemistry. XXII. A "one-pot" synthesis of some 4-acylpyrrole-2-carboxaldehydesfrom pyrrole. Canadian Journal of Chemistry, 58 (23). pp. 2527-2530. DOI 10.1139/v80-404
Full text not available from this repository.Abstract
The Vilsmeier-Haack intermediates formed from pyrroleand from 1-methylpyrrole may be acylated under normal Friedel-Crafts conditions. Hydrolytic work-up then gives 4-acylpyrrole-2-carboxaldehydes in good yield. The methoxidelmethanol treatment of the 4-trichloroacetylated intermediate leads to methyl 2-formylpyrrole-4-carboxylate. These are all "one-pot" syntheses from pyrrole. The formyl group has been removed from several of the products thus affording some 3-acylpyrroles in two operations.
| Item Type: | Article |
|---|---|
| Subjects: | 99 - Other |
| Divisions: | 99 - Other |
| Journal or Publication Title: | Canadian Journal of Chemistry |
| Volume: | 58 |
| Page Range: | pp. 2527-2530 |
| Identification Number: | 10.1139/v80-404 |
| Depositing User: | Sarah Humbert |
| Date Deposited: | 26 Oct 2011 09:26 |
| Last Modified: | 23 Jul 2013 10:02 |
| URI: | http://eprints.esc.cam.ac.uk/id/eprint/2220 |
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