Differential activity of leukotrienes upon human pulmonary vein and artery.

Schellenberg, R Robert and Foster, Aidan (1985) Differential activity of leukotrienes upon human pulmonary vein and artery. Prostaglandins, 27 (3). pp. 475-482. DOI https://doi.org/10.1016/0090-6980(84)90205-3

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Responses to leukotrienes B4, C4, D4 and E4 were examined in human pulmonary artery and pulmonary vein preparations from surgical specimens. Leukotrienes C4 (LTC) and D4 (LTD) were potent contractants of pulmonary vein over the dose range of 10(-10) M to 10(-6) M, whereas they produced minimal contractions of human pulmonary artery only at concentrations of 10(-8) M or greater. Leukotriene E4 was less potent than LTC or LTD, and leukotriene B4 (LTB) at concentrations up to 10(-6) M had no effect upon either pulmonary veins or pulmonary arteries. Contractions of pulmonary vein by LTD were inhibited in a competitive manner by FPL 55712. Dose response characteristics of LTD and inhibition by FPL 55712 were similar for pulmonary venous and bronchial smooth muscle. We conclude that pulmonary vein smooth muscle has leukotriene receptors comparable to those of bronchial smooth muscle whereas pulmonary artery does not.

Item Type: Article
Subjects: 99 - Other
Divisions: 99 - Other
Journal or Publication Title: Prostaglandins
Volume: 27
Page Range: pp. 475-482
Identification Number: https://doi.org/10.1016/0090-6980(84)90205-3
Depositing User: Sarah Humbert
Date Deposited: 26 Oct 2011 09:33
Last Modified: 23 Jul 2013 10:02
URI: http://eprints.esc.cam.ac.uk/id/eprint/2222

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