Ionic co-crystals of organic molecules with metal halides: A new prospect in the solid formulation of active pharmaceutical ingredients

Braga, Dario and Grepioni, Fabrizia and Lampronti, Giulio I. and Maini, Lucia and Turrina, Alessandro (2011) Ionic co-crystals of organic molecules with metal halides: A new prospect in the solid formulation of active pharmaceutical ingredients. Crystal Growth & Design, 11 (12). pp. 5621-5627. ISSN 1528-7483, ESSN: 1528-7505 DOI https://doi.org/10.1021/cg201177p

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Abstract

Ionic co-crystals (ICCs) are constituted of inorganic salts and organic molecules. These crystals combine ionic interactions with classical supramolecular bonding such as hydrogen and dipole-bonding interactions. Such is the case of the hydrogen bonds between N–H and C═O dipoles in primary and secondary amides when these cocrystallize with an ionic material such as CaCl2. Here, we report our results of the preparation and characterization of a series of ICCs in which the molecular component is an active pharmaceutical ingredient (API) or a precursor of APIs, namely, barbituric acid, diacetamide, malonamide, nicotinamide, and piracetam, while the inorganic salt coformer is CaCl2. CaCl2 has been chosen, inter alia, for its nontoxicity and potential applications in the pharmaceutical field. Preparative methods include conventional crystallizations from solution, as well as slurry and solid state techniques (grinding and kneading). All crystal structures reported herein were determined either from single crystal diffraction data or from powder diffraction data, using simulated annealing procedures. Crystalline products were analyzed by differential scanning calorimetry, thermogravimetric analysis, and variable temperature X-ray powder diffraction. Intrinsic dissolution rate measurements were also performed on nicotinamide and piracetam ICCs.

Item Type:	Article
Uncontrolled Keywords:	NILAREP
Subjects:	03 - Mineral Sciences
Divisions:	03 - Mineral Sciences 99 - Other
Journal or Publication Title:	Crystal Growth & Design
Volume:	11
Page Range:	pp. 5621-5627
Identification Number:	https://doi.org/10.1021/cg201177p
Depositing User:	Giulio Isacco Lampronti
Date Deposited:	14 Aug 2015 17:01
Last Modified:	14 Aug 2015 17:11
URI:	http://eprints.esc.cam.ac.uk/id/eprint/3436

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