Tracing Bioavailability of ZnO Nanoparticles Using Stable Isotope Labeling

Larner, Fiona and Dogra, Yuktee and Dybowska, Agnieszka and Fabrega, Julia and Stolpe, Bjoern and Bridgestock, Luke J. and Goodhead, Rhys and Weiss, Dominik J. and Moger, Julian and Lead, Jamie R. and Valsami-Jones, Eugenia and Tyler, Charles R. and Galloway, Tamara S. and Rehkaemper, Mark (2012) Tracing Bioavailability of ZnO Nanoparticles Using Stable Isotope Labeling. Environmental Science & Technology, 46 (21). pp. 12137-12145. ISSN 0013-936X

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Abstract

Zinc oxide nanoparticles (ZnO NPs) are widely used in commercial products and knowledge of their environmental fate is a priority for ecological protection. Here we synthesized model ZnO NPs that were made from and thus labeled with the stable isotope Zn-68 and this enables highly sensitive and selective detection of labeled components against high natural Zn background levels. We combine high precision stable isotope measurements and novel bioimaging techniques to characterize parallel water borne exposures of the common mudshrimp Corophium volutator to (ZnO)-Zn-68 NPs, bulk (ZnO)-Zn-68, and soluble (ZnCl2)-Zn-68 in the presence of sediment. C. volutator is an important component of coastal ecosystems where river-borne NPs will accumulate and is used on a routine basis for toxicity assessments Our results demonstrate that ionic Zn from ZnO NPs is bioavailable to C volutator and that Zn uptake is active. Bioavailability appears to be governed primarily by the dissolved Zn content of the water, whereby Zn uptake occurs via the aqueous phase and/or the ingestion of sediment particles with adsorbed Zn from dissolution of ZnO particles. The high sorption capacity of sediments for Zn thus enhances the potential for trophic transfer of Zn derived from readily soluble ZnO NPs. The uncertainties of our isotopic data are too large, however, to conclusively rule out any additional direct uptake route of ZnO NPs by C. volutator.

Item Type: Article
Subjects: 01 - Climate Change and Earth-Ocean Atmosphere Systems
Divisions: 01 - Climate Change and Earth-Ocean Atmosphere Systems
Journal or Publication Title: Environmental Science & Technology
Volume: 46
Page Range: pp. 12137-12145
Depositing User: Sarah Humbert
Date Deposited: 22 Nov 2020 23:57
Last Modified: 24 Nov 2020 19:07
URI: http://eprints.esc.cam.ac.uk/id/eprint/4913

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